재단사업

2009 ㅣ 특집

This study aimed to assess the cost effectiveness of pharmacists
intervention(improved dosing schedules: simplifying the regimen to daily dosing)to patients
with type 2 dibetes. From April to May 2010, 41 outpatients taking sulfonylurea as oral
hypoglycemic agent in endocrine department of Seoul St. Mary Hospital were divided into
two groups ; Group A kept taking sulfonylurea medication before meal while group B
changed the time of administration to immediately after meal. After follow-up until
November 2010, changes in compliance on medication measured by Morisky's scale(6:low,
6~7:medium, 8:high), HbA1C(%) and the cost were compared respectively. No significant
differences in compliance, HbA1c and the cost were found between two groups. However,
when the group B was divided into moderate compliance group(Morisky’s scale≥6) and poor
compliance group(Morisky’s scale≤5), the compliance was significantly enhanced(1.3±1.3
vs. -0.5±0.8 p=0.0001) in the poor compliance group while there was no significant difference in HbA1c. Although the effects of the improved medication compliance on glycemic
control and the cost were not clearly investigated in this study, the findings of this study
indicated that medication compliance was improved by simplifying the regimen especially in the patients with poor compliance from the initial state. Further research with expanded
study period is needed to determine the effects of improved compliance on treatment outcome and the cost.